Role of Sphingolipids in Pulmonary Edema (09-045)

RWTH Aachen University

Status: Completed

Conditions: Pulmonary Edema

Study type: Observational

Funder types: Other

Identifiers

NCT01162161

Sphingo-AC

Details and patient eligibility

About

In this mono-center prospective study, the impact of changes in the sphingolipid metabolism in patients with pulmonary edema will be investigated.

Full description

There will be three groups of patients:

1. hydrostatic pulmonary edema
2. toxic pulmonary edema
3. not ventilated patients without any pulmonary edema

Samples of a routine bronchoalveolar lavage and EDTA-blood will be analysed in respect of sphingolipids, ceramide, sphingomyelin-phosphodiesterase and several cytokines.

Enrollment: 45 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• above the age of 18

Exclusion criteria

• taking steroids

Trial design

45 participants in 3 patient groups

hydrostatic pulmonary edema

Description:

patients with a pulmonary edema caused by chronic heart failure

toxic pulmonary edema

Description:

patients with a pulmonary edema preceded by pneumonia

control group

Description:

not ventilated patients without any pulmonary edema receiving a bronchoscopy due to another pulmonary problem (no pneumonia, no heart failure)