Role of ST2 in Acute Pancreatitis

Free University of Brussels (ULB)

Status: Completed

Conditions: Acute Pancreatitis

Study type: Observational

Funder types: Other

Identifiers

NCT01315613

RO-ST2

Details and patient eligibility

About

Acute pancreatitis is characterized by an inflammatory storm which regulatory pathways are not well known. The IL-1 cytokine family is activated early during acute pancreatitis and secretion of alarmins is speculated during pancreatic necrosis. IL-33 is a member of the IL-1 family, it can act as an alarmin and its receptor, ST2, is known to sequester MyD88 which might regulate the acute pancreatitis inflammatory storm. The aim of this study is to investigate ST2 pathway in human acute pancreatitis and in murine experimental models of acute pancreatitis.

Enrollment: 44 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Time to take blood sample less than 24h after the onset of symptoms of AP
• Two of the following: typical pain, amylase and lipase concentrations more than 3x the upper normal limit, compatible modifications on imaging techniques

Exclusion criteria

• Chronic pancreatitis

Trial design

44 participants in 1 patient group

Acute pancreatitis

Description:

Patients admitted in our institution for an episode of acute pancreatitis