Role of SWE-change After TIPS in the Prediction of Prognosis After TIPS (TIPS-SWE)

Jonel Trebicka

Status: Completed

Conditions: Liver Cirrhoses; Portal Hypertension

Treatments: Diagnostic Test: Stiffness measurement

Study type: Observational

Funder types: Other

Identifiers

NCT03072615

TIPS-SWE

Details and patient eligibility

About

The aim of our prospective multicenter study was to investigate the prognostic value of the acute and long-term changes of liver stiffness in patients receiving a transjugular intrahepatic portosystemic shunt (TIPS).

Full description

We included 83 patients receiving TIPS for prevention of rebleeding, therapy-refractory ascites or both. Hemodynamic parameters were assessed before TIPS and after TIPS insertion. 16 patients from Freiburg underwent TE immediately before and after TIPS. In 67 patients from Bonn, SWE of liver and spleen, as well as clinical and biochemical parameters were assessed before TIPS, seven days and six weeks after TIPS.

Enrollment: 83 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• TIPS insertion and had reliable SWE or TE measurement

Exclusion criteria

• contraindication for TIPS
• no reliable SWE or TE measurement

Trial design

83 participants in 2 patient groups

1

Description:

receiving TE before and 30 min after TIPS

Treatment:

Diagnostic Test: Stiffness measurement

2

Description:

receiving SWE before and 7 days, 6 weeks and 3 months after TIPS

Treatment:

Diagnostic Test: Stiffness measurement