Role of the Interaction Between Advanced Glycation End Products and Their Receptor RAGE in the Development and the Progression of the Uremic Vasculopathy of Hemodialyzed Patients (RAGE-VASCU)

CHU de Reims

Status

Completed

Conditions

Hemodialyzed Patients

Treatments

Biological: Blood sample withdrawn

Other: Vascular calcifications by tomodentimetry

Other: Vascular calcifications by Xray

Study type

Interventional

Funder types

Other

Identifiers

NCT02818465

PR14037

Details and patient eligibility

About

Chronic kidney disease (CKD) is associated with an extensive vasculopathy and high cardiovascular mortality as well as an accumulation of uremic toxins. Among the latest, advanced glycation end-products (AGEs) interact with RAGE. Investigators aimed to analyze the role of RAGE in the calcification process of hemodialyzed patients, in a correlative and prospective study. Vascular calcifications will be assessed by Xray and tomodentimetry while accumulation of AGEs will be measured in the serum and in the skin (non invasive). Additionally factors influencing RAGE activation such as genetic polymorphism and level of soluble forms of RAGE will be measured and analyzed.

Enrollment

100 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Renal impairment
Hemodialysis for more than 3 months
Have agreed to participate in research
Affiliated to a social security scheme
major

Exclusion criteria

Diabetes , for diabetes induces accelerated formation of advanced glycation end products , which could then be a confounding factor in our study.
Protected by law .
minors
pregnant women
Matt or pigmented skin because the skin hyperpigmentation interfere with reading the skin fluorescence giving falsely elevated values .
Having an aneurysm of the abdominal aorta known
Suffering from a progressive neoplastic disease