Role of the Peritoneal Microenvironment in the Pathogenesis and Spread of Colorectal Carcinomatosis (MMT)

Ghent University Hospital (UZ)

Status: Completed

Conditions: Peritoneal Carcinomatosis

Treatments: Procedure: Sampling peritoneal tissue

Study type: Observational

Funder types: Other

Identifiers

NCT03777943

EC/2017/0784

Details and patient eligibility

About

The goal of this project is to investigate the extent and role of mesothelial - mesenchymal transition (MMT) and cancer associated fibroblasts (CAFs) in the pathogenesis of colorectal peritoneal carcinomatosis (PC).

Enrollment: 53 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients presenting with colorectal peritoneal carcinomatosis

Exclusion criteria

• Pregnancy or breast feeding
• Psychiatric pathology capable of affecting comprehension and judgment faculty
• HIPEC (hyperthermic intraperitoneal chemotherapy) or PIPAC (pressurized intraperitoneal aerosol chemotherapy) in the past
• Abdominal radiation treatment

Trial design

53 participants in 1 patient group

Cytoreductive surgery (CRS)

Description:

In patients presenting with colorectal peritoneal carcinomatosis, peritoneal tissue will be sampled during surgery at 4 different locations.

Treatment:

Procedure: Sampling peritoneal tissue