Role of the Posterior Parietal Cortex in the Processing of Sensory Information (CORTEX)

University Hospital, Lille

Status: Unknown

Conditions: Healthy Subject

Treatments: Device: Electrical Muscle Activity (EMG); Device: Transcranial Magnetic Stimulation (TMS)

Study type: Interventional

Funder types: Other

Identifiers

NCT03386188

2014-A01507-40 (Other Identifier)

2014_32

Details and patient eligibility

About

Although the primary motor cortex is considered has the common final pathway of motor commands, it is influenced by several structures as, for example, the premotor cortex and the posterior parietal cortex which are involved in motor planning and programming and which integrates movement-induced sensory impute (parieto-frontal circuits). Several studies have shown that there are some direct functional connections between the premotor cortex and the posterior parietal cortex and from these two regions to the primary motor cortex. The posterior parietal cortex can then be considered as a sensorimotor interface whose function in planification and motor control of upper limb is well demonstrated. The hypothesis is that the posterior parietal cortex could participate to the modulation of motor cortex excitability by proprioceptive sensory inputs namely long latency afferent inhibition and afferent induced facilitation.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Right handed
• No neurological troubles
• Informed consent signed
• Affiliated to a social security

Exclusion criteria

• Psychiatric antecedent
• Neurological disease
• Contra-indication to TMS
• Under psychiatric treatment
• Pregnancy
• Contra-indication to MRI

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

Healthy arm

Experimental group

Description:

posterior parietal cortex (PPC) transitory inactivation

Treatment:

Device: Transcranial Magnetic Stimulation (TMS)

Device: Electrical Muscle Activity (EMG)