Role of the Renin Angiotensin Aldosterone System in the Mechanisms of Transition to Heart Failure in Abdominal Obesity (R2C2-II)

Central Hospital, Nancy, France

Status: Completed

Conditions: Obesity, Abdominal

Treatments: Other: Blood sample; Other: Echotracking; Other: Pulse wave velocity; Other: Glucose tolerance test; Other: cardiac and abdominal magnetic resonance imaging; Other: Assessment of sleep apnea syndrome; Other: Urine sample; Other: Composition of body mass by Dual x-ray absorptiometry; Other: Ambulatory blood pressure monitoring; Other: Electrocardiogram; Other: Echocardiography

Study type: Interventional

Funder types: Other

Identifiers

NCT01716819

2012-A00574-39

Details and patient eligibility

About

R2C2 study has shown that abdominal obesity is associated with a cardiac and vascular remodelling in healthy volunteers. This remodelling is correlated with renin-angiotensin aldosterone system (RAAS) activation and/or systemic fibrosis. R2C2 II study is designed to confirm the hypothesis that RAAS is associated with an early remodelling and implicated in the transition to cardiac failure in abdominal obesity.

Full description

Follow up of abdominal obesity patients from the R2C2 cohort study.

Enrollment: 101 patients

Sex: All

Ages: 43 to 72 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Being a former member of R2C2 study, abdominal obese group.
• Having signed the informed consent (refusing to participate to the genetic study is not an exclusion criteria).
• being affiliated to health insurance scheme.

Inclusion Criteria of R2C2 study:

• Men and women aged between 40 and 65 year's old
• Caucasian
• Born or living in France for at least 10 years
• Presenting an abdominal obesity defined by a waist circumference >94 cm in men and ≥ 80 cm in women, associated or not with untreated hypertension or hypertension treated for less than one year
• Having signed the informed consent

Exclusion criteria

• Subjects unable to understand the information letter
• Subjects under supervision or guardianship
• pregnant or lactating woman
• A contraindication to perform MRI is not an exclusion criteria.

Trial design

101 participants in 1 patient group

Abdominal obesity

Other group

Description:

Single arm, follow up cohort in patient with abdominal obesity. No comparator: description of interventions : Composition of body mass by Dual x-ray absorptiometry Pulse wave velocity Electrocardiogram Urine sample Blood sample (and biological collection) Assessment of sleep apnea syndrome Glucose tolerance test Echocardiography Echotracking cardiac and abdominal magnetic resonance imaging Ambulatory blood pressure monitoring

Treatment:

Other: Glucose tolerance test

Other: cardiac and abdominal magnetic resonance imaging

Other: Electrocardiogram

Other: Echocardiography

Other: Pulse wave velocity

Other: Blood sample

Other: Echotracking

Other: Ambulatory blood pressure monitoring

Other: Composition of body mass by Dual x-ray absorptiometry

Other: Assessment of sleep apnea syndrome

Other: Urine sample