Role of the Stress in the Development of the Metabolic Syndrome (STREX)

Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina

Status: Unknown

Conditions: Depressive Disorders; Anxiety Disorders; Stress Disorders; Metabolic Syndrome

Study type: Observational

Funder types: Other

Identifiers

NCT01538082

7Z08/002

Details and patient eligibility

About

The purpose of this study is determine the incidence of metabolic syndrome (MetS) in people of high risk, of 40 or more years and attended in the Primary Care. Evaluating the association between anxiety, depression, quality of life and the vital stressful events, and the development of the metabolic syndrome in general population.

Our hypothesis is that population of the cohort with bigger degree of stress will develop earlier the metabolic syndrome.

If our hypothesis about the metabolic syndrome are demonstrated, it would allow establishing in a future interventions on these factors of risk to prevent or to decrease the incidence of this syndrome in the Primary Care.

Enrollment: 738 estimated patients

Sex: All

Ages: 40+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Both genders, elderly than 40 years

• Subjects with 1 or 2 criteria of NCEP-ATPIII set for Metabolic Syndrome

  • Abdominal waist > 102 cm ( men ) or >88 cm ( women )
  • Blood Pressure ( >130/85 mmHg ) ( or else pharmacologic treatment of hypertension )
  • Hypertriglyceridaemia ( >150 mg/dl ) ( or else pharmacologic treatment )
  • HDL-cholesterol <40 mg/dl ( men ) or <50 mg/dl ( women ) ( or else treatment )
  • Fasting glucose > 110 mg/dl.

Exclusion criteria

• Metabolic Syndrome (NCEP-ATPIII defined)(3 criteria of above mentioned)
• Severe or terminal disease
• Severe mental disease that difficulties the follow-up

Trial design

738 participants in 2 patient groups

Patients without stress

Description:

Patients without any of the next items: Zung's questionnaire score over 19 points; SF-12 questionnaire score over 5 points; Stressful vital events score over 150 points.

Patients with stress

Description:

Patients with stress, including: Zung's questionnaire punctuation over 19 points; SF-12 questionnaire score over 5 points; stressful vital events score over 150 points. All combinations are considered positive in stress.