Role of the Sympathetic Nervous System in Rosacea

Kristen Metzler-Wilson

Status

Enrolling

Conditions

Rosacea

Treatments

Other: systemic and local stressors

Study type

Interventional

Funder types

Other

NIH

Identifiers

NCT03989492

95771

1R15AR069912-01A1

Details and patient eligibility

About

Rosacea is a common skin disorder which causes facial redness and inflammation in about 16 million Americans, from an unknown cause. Many triggers of rosacea symptoms are stressors that affect the sympathetic ("fight or flight") portion of the nervous system, and a recent pilot study suggests there is sympathetic dysfunction in rosacea. This project will benefit patients, clinicians, and basic scientists by increasing our understanding of sympathetic nervous system involvement in rosacea symptoms in order to develop improved treatments for patients with rosacea.

Enrollment

210 estimated patients

Sex

All

Ages

18 to 45 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Otherwise healthy males and non-pregnant/non-lactating females with mild to moderate erythematotelangiectactic rosacea, as well as age-sex matched healthy control subjects.

Exclusion criteria

Neurological, cardiovascular, respiratory, metabolic, muscular, or other dermatological disorders
Current history of alcohol and/or drug abuse
Known allergies or hypersensitivities to medications/drugs that are used in the protocol
Current smoking or regular smoking within the last 2 years
Body mass index > 35 kg/m2
Medications or supplements which are known to affect neural, cardiovascular, or muscular responses