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Role of Ultrasound Guide Greater Occipital Nerve Block at Second Cervical Vertebra in Migraine Headache Prophylaxis

M

Mahidol University

Status and phase

Not yet enrolling
Phase 4

Conditions

Migraine Disorders

Treatments

Drug: Placebo
Drug: Bupivacaine

Study type

Interventional

Funder types

Other

Identifiers

NCT06432127
256/2024

Details and patient eligibility

About

The goal of this randomized controlled study in Thailand. is to find if there is a role of local anesthetic greater occipital nerve block at Cervical spine level 2 under ultrasound guide in prophylaxis of episodic migraine and chronic migraine in patients with failed oral prophylaxis medication.

According to guidelines of the International Headache Society for controlled trials of preventive treatment of migraine attacks in episodic and chronic migraine,the primary and secondary outcome were monitoring followed by these research guideline

After informed consent, volunteer will be stratified random into 2 groups of injection agent at unilateral greater occipital nerve block on headache site under US guide by pain physician

  • Normal saline
  • 0.5% bupivacaine the injection was done 2 times between Week 0 and week 4 as to wean off placebo effect the volunteer will be monitor by pain diary at 1 month before intervention at week 0,4,8,12 and follow up at week 24 for Migraine Disability Assessment Test (MIDAS) ,Thai Hospital-Anxiety-depression index(Thai-HADS)

Full description

  • Neurologist screening candidate volunteers for this study, following the inclusion and exclusion criteria
  • Candidate volunteers attended pain clinic for he protocol detail about this research and informed consent
  • After signing consent, Volunteers would be stratified randomization into 2 groups between Normal saline and bupivacaine
  • Volunteers would be done base line headache diary for 1 month before performing the procedure (Week -4 to week0)
  • At Week 0, Volunteers would be applied local anesthetic cream at skin injection site before done the procedure
  • According to stratified randomization, Pain interventionist and also volunteers would be blinded to the group
  • First Unilateral greater occipital nerve block at Cervical spine level 2 (C2) was done under ultrasound guide (Week0)
  • Telemedicine Follow up at week 2
  • Second Unilateral greater occipital nerve block at C2 level was done under ultrasound guide (Week4)
  • Volunteers would be follow up via telemedicine and done headache diary until 3 months after 1st injection
  • Volunteers would be follow up according to outcome monitoring protocol in Week 0,4,8,12,24

Enrollment

108 estimated patients

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  1. Age 18 -65 years old
  2. Diagnosis as episodic migraine or chronic migraine and had indication to use migraine prophylaxis
  3. Volunteer prefer to use research procedure as first choice of migraine prophylaxis
  4. Volunteer already had migraine prophylaxis treatment but still has the one of these following problem 4.1 Frequency of migraine attack more than 4 times/month 4.2 Severe migraine headache & disturb daily life in spite of using migraine prophylaxis 4.3 Having migraine medication side effect, either from prophylaxis or acute attack medication and cannot titration medication dosage 4.4 migraine attack not improved as using many migraine prophylaxis medications 4.5 Having contra-indication to use prophylaxis migraine medication or standard prophylaxis procedure such as botulinum toxin 4.6 Cannot take prophylaxis medication daily (low compliance) 4.7 Had financial problems in using standard prophylaxis migraine medication or procedure 4.8 Medication overuse headache

Exclusion criteria

  1. Had these type of headache in combination with migraine

    • cervicogenic headache
    • occipital neuralgia
    • secondary headache
  2. Had contraindication on greater occipital nerve block injection at cervical spine level 2 under ultrasound-guided such as skin infection in needle site

  3. Allergy to local anesthetic

  4. Uncontrolled psychiatric disorder in 3 months before attending research

  5. Cannot understand or reading, writing Thai language

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Triple Blind

108 participants in 2 patient groups, including a placebo group

Placebo
Placebo Comparator group
Description:
Use Normal saline 3 ml as the injection agent
Treatment:
Drug: Placebo
Bupivacaine
Experimental group
Description:
Use 0.5% Bupivacaine 3ml as the injection agent
Treatment:
Drug: Bupivacaine

Trial contacts and locations

1

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Central trial contact

RAVIWON ATISOOK, M.D.

Data sourced from clinicaltrials.gov

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