Role of Volatile Anesthetics for Hepatic Protection

University of Zurich (UZH)

Status: Completed

Conditions: Reperfusion Injury

Treatments: Drug: Sevoflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT00516711

StV 5-2006

Details and patient eligibility

About

This study aims to evaluate the attenuation of ischemic-reperfusion injury in the liver after sevoflurane preconditioning. In the presence of sevoflurane, an attenuation of liver injury is hypothesized (diminished increase of liver enzymes, reduced production of inflammatory mediators).

Full description

Organ protection; preconditioning; volatile anesthetics; ischemia reperfusion

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Older than 18 years of age
• Patients undergoing liver resection (benign or malignant tumors)

Exclusion criteria

• Laparoscopic liver resection coagulopathy (platelets < 50,000/ml, Quick < 50%)
• Liver cirrhosis

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)