Ropivacaine/Dexamethasone and 10% Lignocaine Injection in GPN Block for Intractable Cancer Pain

All India Institute Of Medical Science (AIIMS)

Status: Unknown

Conditions: Cancer Pain; Cancer, Oropharynx; Pain, Intractable

Treatments: Procedure: 10% lignocaine injection; Procedure: 0.75 % Ropivacaine/ 4mg/mL dexamethasone injection

Study type: Interventional

Funder types: Other

Identifiers

NCT04085120

IEC-402/07.06.2019, RP-34/2019

Details and patient eligibility

About

The study will compare the efficacy and safety of Ropivacaine/dexamethasone vs 10% lignocaine injection in distal glossopharyngeal nerve block for intractable cancer pain

Enrollment: 60 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with proven carcinoma of the oropharynx and supraglottic larynx with estimated survival of 3 months or more.
• Pain lasting for at least 2 weeks with an average intensity of 5 or more on an 11-point numeric rating scale (NRS) refractory to a combination strong opioids and NSAIDS

Exclusion criteria

1. Local infection or skin ulceration at the puncture site
2. Local anaesthetic allergy
3. Psychiatric illness that affected cooperation.

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 2 patient groups

Ropivacaine/dexamethasone group

Experimental group

Description:

3ml of 0.75% ropivacaine and 1ml of 4mg/l dexamethasone will be injected.

Treatment:

Procedure: 0.75 % Ropivacaine/ 4mg/mL dexamethasone injection

10% lignocaine injection group

Experimental group

Description:

4 ml of 10% lignocaine

Treatment:

Procedure: 10% lignocaine injection