ROS Signaling in Endothelial Function

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Boston University

Status

Completed

Conditions

Cardiovascular Disease

Treatments

Drug: N-acetylcysteine
Drug: Placebo

Study type

Interventional

Funder types

Other

Identifiers

NCT01037465
H-26547

Details and patient eligibility

About

The vascular endothelium (inner lining of cells in blood vessels) normally prevents vasospasm and thrombosis by producing nitric oxide and other regulatory substances. In patients with atherosclerosis, endothelial function is impaired. Excess production of reactive oxygen species (free radicals) contribute to endothelial dysfunction in atherosclerosis, and some prior studies have shown a beneficial effect of antioxidant treatment on endothelial function in patients with coronary artery disease. On the other hand, reactive oxygen species may be required for normal endothelial function and antioxidant supplements failed to show a benefit in large clinical trials. The effect of antioxidant treatment on endothelial function in healthy subjects is unknown. The present study will test the hypothesis that scavenging reactive species might reduce endothelium-dependent vasodilation in healthy subjects. The study is a randomized, double-blind, placebo-controlled crossover study. Participants will receive 2.4 grams of oral NAC or similar-appearing placebo during the first visit, and then will cross over to the alternative treatment (NAC or placebo) for the second and final visit. We will examine endothelial function before and after treatment on each visit.

Enrollment

72 patients

Sex

All

Ages

21 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Sex: Male and Female subjects.
  • Age range: 21-65 years old.
  • Disease status: No acute, chronic, or debilitating medical condition or use of prescribed medications.
  • Willingness and ability to provide written informed consent and the ability to understand, to participate and to comply with the study requirements.

Exclusion criteria

  • Women with a positive urine beta HCG pregnancy test and lactating women.
  • Blood pressure greater than 140/90 mmHg; serum LDL cholesterol greater than 160 mg/dl; fasting blood sugar greater than 110 mg/dl.
  • History of any cigarette smoking within one year of the study.
  • Clinical history of any acute, chronic, or debilitating medical condition, including liver disease and peptic ulcer disease.
  • Treatment with an investigational new drug within the last 30 days.
  • History of a psychological illness or condition such as to interfere with the subject's ability to understand the requirements of the study.

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Double Blind

72 participants in 2 patient groups, including a placebo group

N-acetylcysteine
Active Comparator group
Description:
N-acetylcysteine
Treatment:
Drug: N-acetylcysteine
Placebo
Placebo Comparator group
Description:
Placebo
Treatment:
Drug: Placebo

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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