ROTEM Assessment of Modern Crystalloid, Hydroxyethyl Starch and Gelatin Effect on Coagulation

University Hospital, Motol

Status: Completed

Conditions: Coagulopathy

Treatments: Other: hydroxyethyl starch

Study type: Observational

Funder types: Other

Identifiers

NCT03674684

14092018 Motol Hospital

Details and patient eligibility

About

Modern crystalloid and colloid solutions are balanced solutions which are increasingly used in perioperative period. However, studies investigating their negative effect on whole blood coagulation are missing. The aim of our study was to assess the effect of modern balanced crystalloid and colloid solutions on whole blood coagulation in vivo using rotational thromboelastometry.

Full description

Blood samples were obtained from 30 patients during knee arthroscopy before and after administration of 500 ml of modern balanced crystalloid, hydroxyethyl starch (HES) or gelatin. Rotational thromboelastometry (EXTEM, INTEM and FIBTEM tests) were performed to assess negative effect of fluid solutions on whole blood coagulation.

Enrollment: 30 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy patients undergoing knee arthroscopy

Exclusion criteria

• receiving antiplatelet drugs

Trial design

30 participants in 3 patient groups

hydroxyethyl starch

Description:

Patients who received hydroxyethyl starch

Treatment:

Other: hydroxyethyl starch

gelatin

Description:

Patients who received gelatin

Treatment:

Other: hydroxyethyl starch

crystalloids

Description:

Patients who received crystalloids

Treatment:

Other: hydroxyethyl starch