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rTMS for Apathy Clinical Trial (REACT)

S

Sunnybrook Health Sciences Centre

Status

Enrolling

Conditions

Apathy in Dementia
Alzheimer Disease
Mild Cognitive Impairment
Mild Behavioural Impairment
Neurocognitive Disorders
Dementia

Treatments

Drug: methylphenidate
Device: rTMS

Study type

Interventional

Funder types

Other

Identifiers

NCT05561205
SUN-5342

Details and patient eligibility

About

Apathy is a common, early, and disabling symptom in dementias and mild behavioural impairment such as Alzheimer's disease (AD) and is characterized by lack of interest and enthusiasm. Both repetitive transcranial magnetic stimulation (rTMS), a form of non-invasive brain stimulation, and methylphenidate, a medication, have been shown to improve apathy. This pilot study will investigate rTMS as a treatment for apathy in neurocognitive disorders and mild behavioural impairment in individuals receiving methylphenidate and individuals not receiving medication for apathy.

Enrollment

10 estimated patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion criteria

  • mild or major neurocognitive disorder OR mild behavioural impairment
  • Apathy for at least 4 weeks
  • Stable dose of medication (>4 weeks) that may affect cognition or behaviour
  • Care partner who spends at least 10 hours a week with the subject

Exclusion criteria

  • Current major depressive episode
  • Agitation, delusions, hallucination
  • Medical contraindications to rTMS
  • Currently taking an amphetamine product
  • Central nervous system abnormalities, Tourette's syndrome, or motor tics
  • Current participation in another clinical trial

Trial design

Primary purpose

Treatment

Allocation

Non-Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

10 participants in 2 patient groups

rTMS + methylphenidate
Experimental group
Description:
repetitive transcranial magnetic stimulation (rTMS) and methylphenidate
Treatment:
Device: rTMS
Drug: methylphenidate
rTMS only
Experimental group
Description:
repetitive transcranial magnetic stimulation (rTMS) only
Treatment:
Device: rTMS

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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