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RTMS for Apathy Clinical Trial (REACT)

S

Sunnybrook Health Sciences Centre

Status

Enrolling

Conditions

Apathy in Dementia
Alzheimer Disease

Treatments

Drug: methylphenidate
Device: rTMS

Study type

Interventional

Funder types

Other

Identifiers

NCT05561205
SUN-5342

Details and patient eligibility

About

Apathy is a common, early, and disabling symptom in dementias such as Alzheimer's disease (AD) and is characterized by lack of interest and enthusiasm. Both repetitive transcranial magnetic stimulation (rTMS), a form of non-invasive brain stimulation, and methylphenidate, a medication, have been shown to improve apathy. This pilot study will investigate rTMS as a treatment for apathy in AD in individuals receiving methylphenidate and individuals not receiving medication for apathy.

Enrollment

8 estimated patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Major neurocognitive disorder
  • Apathy for at least 4 weeks
  • Stable dose of medication (>4 weeks) that may affect cognition or behaviour
  • Care partner who spends at least 10 hours a week with the subject

Exclusion criteria

  • Current major depressive episode
  • Agitation, delusions, hallucination
  • Medical contraindications to rTMS
  • Currently taking an amphetamine product
  • Central nervous system abnormalities, Tourette's syndrome, or motor tics
  • Current participation in another clinical trial

Trial design

Primary purpose

Treatment

Allocation

Non-Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

8 participants in 2 patient groups

rTMS + methylphenidate
Experimental group
Description:
repetitive transcranial magnetic stimulation (rTMS) and methylphenidate
Treatment:
Device: rTMS
Drug: methylphenidate
rTMS only
Experimental group
Description:
repetitive transcranial magnetic stimulation (rTMS) only
Treatment:
Device: rTMS

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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