rTMS in Facilitation of Working Memory in PD

Taipei Veterans General Hospital

Status: Unknown

Conditions: Parkinson Disease

Treatments: Device: rTMS; Behavioral: Cognitive training program

Study type: Interventional

Funder types: Other

Identifiers

NCT03059212

2014-10-018A

Details and patient eligibility

About

Ten sessions of repetitive transcranial magnetic stimulation yield ability to upregulate the function of primary motor cortex and prefrontal cortex that play key roles in motor and frontal memory processing.

Full description

Excitatory (>3Hz) rTMS could facilitate the brain cortex and neuroplasticity that benefits motor control and working memory when the coil is applied over primary motor cortex or dorsolateral prefrontal cortex.

Enrollment: 60 estimated patients

Sex: All

Ages: 30 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of Parkinson's Disease
• With symptoms of cognitive impairments, such as memory, attention, or language decline.

Exclusion criteria

• History of seizure attack
• Alzheimer's disease
• With cardiac pacemaker implantation

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 3 patient groups

High frequency rTMS

Experimental group

Description:

Real rTMS, one session per day, for 10 days

Treatment:

Device: rTMS

High frequency rTMS with cognitive training

Experimental group

Description:

Real rTMS and cognitive training, one session per day, for 10 days

Treatment:

Behavioral: Cognitive training program

Device: rTMS

Sham rTMS

Sham Comparator group

Description:

Sham rTMS, one session per day, for 10 days

Treatment:

Device: rTMS