rTMS in Treatment of Obsessive Compulsive Disorder (OCD)

Queen's University

Status

Completed

Conditions

Obsessive Compulsive Disorder

Treatments

Device: repetitive transcranial magnetic stimulation

Device: sham (placebo)

Study type

Interventional

Funder types

Other

Identifiers

NCT00616486

psiy-266-07

Details and patient eligibility

About

Low frequency (1Hz) rTMS applied bilaterally and simultaneously over SMA for 6 weeks in addition to the standard treatment regimen for OCD, will lead to significant improvement in patients' symptoms. The clinical improvement detected by YBOCS, CGI and SF-36 QOLS scores will be statistically significant in active treatment group compared to sham (placebo) treatment group.

Enrollment

24 patients

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

signed patient informed consent;
primary obsessive compulsive disorder;
YBOCS score at least 20;
males/females 18-65yrs;
treated with adequate dose of SSRI at least 8 weeks at some stage of illness;
currently using adequate, stable dose of SSRI at least 4 weeks but not responding.

Exclusion criteria

schizophrenia, other psychotic disorders, bipolar I, current major depressive disorder (HDRS(17)>18, substance/alcohol dependence within last 6 months;
severe axis II;
suicidal score>=6 on MINI;
metallic implant in cranium;
severe/unstable medical conditions;
not responding to ECT or had TMS in last 6 months;
history epilepsy;
neurological disorder leading to increased intracranial pressure;
severe cardiac disorder/intracardiac lines, pacemakers;