rTMS-induced Cumulative Pattern of sBDNF in Chronic Schizophrenia

Jeonbuk Provincial Maeumsarang Hospital

Status: Completed

Conditions: Schizophrenia

Treatments: Device: CR Technology, TAMAS for repetitive TMS

Study type: Interventional

Funder types: Other

Identifiers

NCT01427088

rTMS-sBDNF-SPR-2011

Details and patient eligibility

About

This study aims at investigating the neuroplastic potential and the possible factors affecting rehabilitation in chronic schizophrenia patients on stable medication, by investigating the cumulative pattern of serum BDNF representing the neuroplasticity in the brain, through quantitative stimulus such as rTMS.

Full description

Subjects who have been enrolled for this study will take baseline evaluation for sociodemographic data and serum level of BDNF, plasma Prolaction, and magnesium, etc. And then, weekday regular stimulation through rTMS will be applied on DLPFC of brain. After the completion of stimulation for 2 weeks, the change or response of serum BDNF will be analyzed and compared.

Enrollment: 21 patients

Sex: All

Ages: 25 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• duration of illness over 10 years
• on stable medication, antipsychotics
• no change on medication within at least 2 weeks
• Diagnosis of Schizophrenia according to DSM-IV-TR

Exclusion criteria

• left or both-handedness
• anticonvulsant use
• lorazepam equivalent over 3 mg

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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21 participants in 1 patient group

repetitive TMS

Experimental group

Description:

repetitive TMS is a quantified stimulation method of specifie area of brain, for which CR Technology, TAMAS for repetitive TMS was used.

Treatment:

Device: CR Technology, TAMAS for repetitive TMS