rTMS Posterior Parietal Cortex Modulation and Upper Limb Movement After Stroke (PPCstim)

University Hospital, Lille

Status: Unknown

Conditions: Stroke; Brain Connectivity; Transcranial Magnetic Stimulation; Hemiparesis

Treatments: Device: repeated transcranial magnetic stimulation continuous theta-burst stimulation; Device: SHAM repeated transcranial magnetic stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT03323255

2016_36

2016-A01608-43 (Other Identifier)

Details and patient eligibility

About

This study evaluates the effect of a unique session of inhibitory rTMS (cTBS) over the contralesional posterio parietal cortex (PPC) on the spatio-temporal parameters of a pointing movement performed by stroke patients with their paretic upper limb. It will also assess the effects on the resting motor threshold of both hemispheres and on parietopremotor connectivity.

To achieve theses aims, the real cTBS stimulation will be randomly counterbalanced with a SHAM stimulation (in a second session) in a crossover design. Assessments will be performed before and after each stimulation session.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age between 18 and 80y
• Right-handed
• Right hemispheric stroke confirmed by a 3D imaging technique
• at the chronic phase (>6months)
• subject being able to perform a pointing movement of at least 20cm in the anterior space without compensatory movements of the trunk
• informed consent
• Social security affiliation

Exclusion criteria

• Severe comprehension troubles (language, cognitive or psychiatric disorders)
• History of neurological disorders in addition to the stroke
• Locomotor troubles affecting the paretic arm
• Contraindication to rTMS : epilepsy, intracranial metallic foreign body, cochlear implant, unstable fracture of the skull bones, deafness
• pregnancy or breastfeeding
• adult subject to guardianship

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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20 participants in 2 patient groups

cTBS stimulation

Active Comparator group

Description:

continuous theta-burst TMS stimulation (1200 pulses, 50Hz, separated in two sequences of 600 pulses)

Treatment:

Device: repeated transcranial magnetic stimulation continuous theta-burst stimulation

SHAM stimulation (placebo)

Sham Comparator group

Description:

SHAM stimulation

Treatment:

Device: SHAM repeated transcranial magnetic stimulation