rTMS Treatment in Vascular Parkinsonism

Inje University

Status: Not yet enrolling

Conditions: Vascular Parkinsonism

Treatments: Device: Sham rTMS Supplementary motor area; Device: Real rTMS Supplementary motor area

Study type: Interventional

Funder types: Other

Identifiers

NCT03720691

18-0089

Details and patient eligibility

About

Vascular parkinsonism (VP), parkinsonism resulting from ischemic cerebrovascular disease, was suggested in 1929. The main features are wide-based gait, postural instability, and falls, which make patients with VP frustrated. Currently, the treatment is challenging.

Transcranial magnetic stiumation is a noninvasive procedure using electromagnetic induction to stimulate brain, and repetitive transcranial magnetic stiumation (rTMS) can selectively change brain activity to enhance desired effects. The aim of this study is to explore the therapeutic effect of rTMS for the VP.

Enrollment: 32 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Vascular parkinsonism
• age 18 and older

Exclusion criteria

• pregnant or any, other medical, surgical, neurological or psychiatric conditions
• other restrictions which prevent you from undergoing TMS recording, such as; surgically or traumatically implanted foreign bodies such as a pacemaker, an implanted medication pump, a metal plate in the skull, or metal inside the skull or eyes (other than dental appliances or fillings), and/ or heart/cardiac lines
• any past or current history of seizure disorder or epilepsy
• unable to give informed consent

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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32 participants in 2 patient groups

Real rTMS Supplementary motor area

Active Comparator group

Description:

Real rTMS will be applied over the supplementary motor area

Treatment:

Device: Real rTMS Supplementary motor area

Sham rTMS Supplementary motor area

Sham Comparator group

Description:

Sham rTMS will be applied over the supplementary motor area

Treatment:

Device: Sham rTMS Supplementary motor area