rTMS Treatment of Dysphagia in Parkinson's Patients

Ege University

Status: Completed

Conditions: Parkinson's Disease (PD); Dysphagia

Treatments: Device: Repetitive Transcranial Magnetic Stimulation; Other: Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT07221110

E-70198063

Details and patient eligibility

About

The study was conducted with patients with dysphagia who were followed up with Parkinson's disease in the neurology and physical therapy rehabilitation departments. The study is a prospective, double-blind clinical intervention study. Patients were divided into two groups (5 Hz and 10 Hz) and received rTMS (repetitive transcranial magnetic stimulation) treatment. The pharyngeal cortex region was targeted in the intervention. Major aim in the treatment was to examine the difference in clinical response caused by the application of rTMS treatment at different frequencies.

Enrollment: 26 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Parkinson's disease for more than two years
• Moderate-to-severe Parkinson's disease (Hoehn yahr 2-4)
• The patient describing dysphagia symptoms
• Patients being able to give informed consent.

Exclusion criteria

• İntracranial metallic device
• Cardiac pace-maker
• History of seizure
• İntracranial lesion on imaging
• Hydrocephalus
• Antipsychotic use
• Babinski positivity
• Berebellar symptoms
• Depression
• Dementia

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

26 participants in 2 patient groups

5 Hz

Experimental group

Description:

Our patients in this arm will receive 10 sessions of treatment on the rTMS device. The device setting will be 5 Hz. All patients will also receive massako, shaker, triflo and cervical strengthening exercises. Our patients will be evaluated with FEES (Fiberoptic endoscopic swallowing evaluation) before, at the end of the treatment and at the 9th month controls in terms of the status of dysphagia.

Treatment:

Other: Exercise

Device: Repetitive Transcranial Magnetic Stimulation

10 Hz

Experimental group

Description:

Our patients in this arm will receive 10 sessions of treatment on the rTMS device. The device setting will be 10 Hz. All patients will also receive massako, shaker, triflo and cervical strengthening exercises. Our patients will be evaluated with FEES (Fiberoptic endoscopic swallowing evaluation) before, at the end of the treatment and at the 9th month controls in terms of the status of dysphagia.

Treatment:

Other: Exercise

Device: Repetitive Transcranial Magnetic Stimulation