rTMS Treatment of Primary Progressive Aphasia

Chinese Academy of Medical Sciences & Peking Union Medical College

Status: Completed

Conditions: Primary Progressive Aphasia; Repetitive Transcranical Magnetic Stimulation

Treatments: Device: Magstim rTMS

Study type: Interventional

Funder types: Other

Identifiers

NCT04431401

PPA-rTMS

Details and patient eligibility

About

Primary Progressive Aphasia (PPA) is a neurodegenerative disease in which language function is gradually and progressively impaired. Patients will eventually be disabled in communication and have cognition deficits, which put a heavy burden not only on their families but also on the whole society. However, no effective treatment for PPA has been explored so far. The current clinical randomized trial is to study the safety and efficacy of repetitive Transcranial Magnetic Stimulation (rTMS) for the treatment of PPA. Also, multi-modality of neuroimaging techniques, such as functional MRI and PET will be used to investigate brain network changing in this procedure.

Enrollment: 40 patients

Sex: All

Ages: 35 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of PPA

Exclusion criteria

• Scored below 15 on the mini-mental state exam (MMSE)
• history of seizures or unexplained loss of consciousness
• pregnancy
• surgical breach of the skull
• MRI contraindication

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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40 participants in 2 patient groups

rTMS treatment group

Experimental group

Description:

The participants will be divided into the rTMS treatment group and the sham treatment group by means of randomized methods.The protocol of the treatment is to use rTMS with high frequency 10/20Hz 120%RMT 20 times for one month. The device is Magtism rTMS made in London, UK

Treatment:

Device: Magstim rTMS

sham treatment group

Sham Comparator group

Description:

The control group is to receive sham treatment. The device is the same as the one used in the real treatment group.

Treatment:

Device: Magstim rTMS