Running Against Prehypertension Trial (RAPT): A Pilot Trial

University of California San Francisco (UCSF) logo

University of California San Francisco (UCSF)

Status

Completed

Conditions

Prehypertension

Treatments

Behavioral: Educational material control
Behavioral: Group running style A
Behavioral: Group running style B

Study type

Interventional

Funder types

Other

Identifiers

NCT01587183
12-08425

Details and patient eligibility

About

This study will test strategies to help people with prehypertension adopt a running program to reduce their blood pressure in the long term. This study will be a 12 week intervention of about 40 participants randomized to running educational material, group based running instruction, or group based running instruction focused on form and all given the option to use the supplemental mHealth intervention. The purpose of this study is to collect feasibility, acceptability and preliminary efficacy data in preparation for a larger planned NIH-R01 study.

Full description

The UCSF Osher Center for Integrative Medicine has increasingly been investigating lifestyle interventions and their upstream approach to improving health and well-being. Many such lifestyle interventions address health risk nonpharmacologically and present participants with the opportunity to change their overall trajectory of health. Exercise interventions are of particular interest based on evidence of numerous physical and mental health benefits. Our target population in the Running Against Prehypertension Trial (RAPT) was people with upper range prehypertension. By adopting and maintaining a running program, these individuals who are at a high risk of hypertension can avoid a lifetime of medication and chronic disease. The objective of RAPT was to collect feasibility, acceptability and preliminary efficacy data over a 12 week period on a running program aimed at teaching a natural running form called ChiRunning that used the mindful movement principles of Tai Chi. By using this natural running form, participants may increase satisfaction and decrease rates of injury towards greater adherence to the program. Participants were randomized to one of three study arms: 1) intervention, 8 weeks of group training in form focused ChiRunning; 2) active control, 8 weeks of group training focused on conventional running excluding form; or 3) usual care, a self-directed training with educational materials.

Enrollment

22 patients

Sex

All

Ages

18 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • The target population for our proposed study is adults with upper range prehypertension defined by systolic blood pressure in the range of 130-144mmHg or diastolic blood pressure range in the range of 85-94mmHg.
  • Potential participants will have two to three blood pressure screening measurements at least one day apart taken to screen for eligibility.
  • Participants also must not be currently taking antihypertensive medications and must live in the San Francisco Bay Area.

Exclusion criteria

  • Inability to provide informed consent
  • Age < 18 years
  • Inability to run continuously for 5 minutes (required for the gait analysis)
  • A substance or alcohol abuse, mental health, or medical condition that, in the opinion of investigators, will make it difficult for the potential subject to participate in the group intervention
  • A history of cardiovascular disease or coronary artery disease including acute coronary syndrome, heart failure, severe aortic stenosis, acute infection or fever, or resting tachycardia (> 100 bpm)
  • A history of cardiac procedures including coronary artery bypass graft, angioplasty or stent placement.
  • Typical or atypical angina
  • Arrhythmia, alcoholism or other condition that makes accurate BP measurement difficult
  • A diagnosis of diabetes, chronic kidney disease or other condition indicating medication for SBP < 140mmHg
  • Non-English speaking (group training will be given in English)
  • Pregnant or planning to get pregnant during the study period
  • Unwillingness or inability to commit to run/walking up to 30 minutes three times per week
  • Plans to move from the San Francisco Bay area during the study time period
  • Currently exercising at vigorous intensity for greater than 90 minutes per week. Vigorous intensity exercise may include race walking, jogging, running, hiking, swimming laps, or bicycling ≥ 10 miles per hour.
  • BMI > 30

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

22 participants in 3 patient groups

Educational materials control
Other group
Description:
Enhanced usual care
Treatment:
Behavioral: Educational material control
Group running style B
Active Comparator group
Description:
Basic running instruction using group based training.
Treatment:
Behavioral: Group running style B
Group running style A
Experimental group
Description:
Form focused running instruction using group based training.
Treatment:
Behavioral: Group running style A

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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