Rutgers University Study of the Genetics of Kidney Disease (rugcc-kd)

Rutgers The State University of New Jersey

Status: Enrolling

Conditions: Kidney Diseases, Chronic; Kidney Diseases; Kidney Diseases,Cystic; Kidney Disease, End-Stage; Kidney Disease, Chronic; Kidney Disease

Treatments: Other: Health surveys; Genetic: Saliva sample

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT07217535

Pro2025001024

Details and patient eligibility

About

The goal of this observational study is to learn more about how genes impact the risk of kidney disease. Anyone 18 or older living in the US is eligible, and a diagnosis of kidney disease is NOT required. Study participation is online, and it takes about 20 minutes to complete health surveys and request a saliva collection kit sent through US mail. In return, study participants may opt to receive information about their genetic ancestry at no cost.

Full description

This is an online research study to learn more about how genes affect the risk of kidney disease. This is an online research study to learn more about how genes affect the risk of kidney disease. No office visit is required and in return, participants may receive information about their genetic ancestry for free. One in seven individuals in the United States today has chronic kidney disease (CDC 2023). The heritability -a measure of genetic, as opposed to environmental, contribution to a disease- of kidney function such as the estimated glomerular filtration rate (eGFR) has been estimated at 38%This study will increase our understanding of the genetic basis of kidney disease, which is a crucial step in drug development to improve current treatment options. The study investigators seek a diverse population because diversity among participants maximizes the usefulness of the data. Participants will use our online study portal to answer questions about their health and provide their DNA via a saliva sample using a pre-paid mailer. Participation takes approximately 20 minutes. Participants will be invited to share data from their electronic health records, but this is not required for study participation. The study investigators keep participants engaged with short monthly newsletters.

Enrollment: 50,000 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age 18 years or older
• currently living in the United States
• able to understand and follow written instructions in English
• have access to the internet and a computer, laptop, tablet or smart phone
• willing to provide written informed consent for participation
• willing to provide DNA via a saliva sample using a collection kit mailed to the study participant's home
• willing to complete a survey with questions about health related to the study of kidney disease

Exclusion criteria

• Not able to meet or fulfill any of the inclusion criter

Trial design

50,000 participants in 2 patient groups

Kidney disease cases

Description:

Study participants who have been diagnosed with any form of kidney disease, either currently or in the past.

Treatment:

Genetic: Saliva sample

Other: Health surveys

Kidney disease controls

Description:

Study participants who have never been diagnosed with any form of kidney disease, either currently or in the past.

Treatment:

Genetic: Saliva sample

Other: Health surveys