S-cystatin C vs.Injection Clearance Measurements to Estimate Kidney Function in Patients With Spinal Cord Injuries

Rigshospitalet

Status: Completed

Conditions: Renal Failure; Spinal Cord Injuries

Treatments: Other: eGFR estimated from creatinine and cystatin C

Study type: Observational

Funder types: Other

Identifiers

NCT06565351

Rigshospitalet Glostrup;

Details and patient eligibility

About

• In individuals with spinal cord injury (SCI) kidney function defined as Glomerular Filtration Rate (GFR) is monitored by injection of e.g.99mDTPA and subsequent blood sampling (DTPA-clearance)
• GFR calculated from plasma samples of the endogenous substance s-Cystatin C (eGFR cystatin C) was compared to DTPA-clearance in 248 individuals with SCI.
• It is concluded that eGFR based on plasma s-cystatin C can replace the more tedious 99mDTPA-clearance procedures in individuals with SCI

Enrollment: 248 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Neurogenic bladder dysfunction due to spinal cord injury

Exclusion criteria

None

Trial design

248 participants in 1 patient group

Spinal Cord Injury Individuals

Description:

248 individuals with spinal cord injury and neurogenic bladder dysfunction, coming to routine controls of the renal function. Glomerular filtration rate (GFR) was measured by 99mTc-DTPA clearance and estimated by eGFR from creatinine and Cystatine C

Treatment:

Other: eGFR estimated from creatinine and cystatin C