S9304A Study of Protein Expression in Tumor Tissue Samples From Patients With Stage II or Stage III Rectal Cancer Enrolled in Clinical Trial SWOG-9304

S

SWOG Cancer Research Network

Status

Completed

Conditions

Colorectal Cancer

Study type

Observational

Funder types

NETWORK
NIH

Identifiers

NCT00972751
SWOG-9304A-ICSC (Other Identifier)
CDR0000601255
U10CA032102 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict how patients will respond to treatment. PURPOSE: This research study is looking at protein expression in tumor tissue samples from patients with stage II or stage III rectal cancer enrolled in clinical trial SWOG-9304.

Full description

OBJECTIVES: Determine expression levels of thioredoxin-1 (Trx-1), thioredoxin-interacting protein (TXNIP), and hypoxia inducible factor-1 alpha (HIF-1α) in paraffin-embedded resected tumor tissue samples from patients with stage II or III rectal cancer enrolled in clinical trial SWOG-9304. Determine if there is a correlation between Trx-1 and TXNIP expression and HIF-1α expression. Correlate expression of these proteins with tumor stage, disease-free survival, overall survival, and risk of recurrence. Determine interactions for patient age, performance status, and type of therapy received on clinical trial SWOG-9304. OUTLINE: This is a multicenter study. Paraffin-embedded resected tumor tissue samples are analyzed for protein expression levels (thioredoxin-1, thioredoxin-interacting protein, and hypoxia inducible factor-1 alpha) by tissue microarray and immunostaining.

Enrollment

220 patients

Sex

All

Ages

18 to 120 years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

DISEASE CHARACTERISTICS:

Histologically confirmed adenocarcinoma of the rectum

  • Stage II or III disease
  • No metastases
  • Enrolled on clinical trial SWOG-9304

PATIENT CHARACTERISTICS:

Not specified

PRIOR CONCURRENT THERAPY:

See Disease Characteristics

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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