Sacral Neuromodulation and Pudendal Somatic Afferents

Universiteit Antwerpen

Status: Unknown

Conditions: Overactive Bladder, Non Obstructive Urinary Retention

Treatments: Diagnostic Test: Somatosensory evoked potentials

Study type: Observational

Funder types: Other

Identifiers

NCT03614754

17/30/334

Details and patient eligibility

About

Sacral neuromodulation is a well-excepted minimally invasive procedure for the treatment of overactive bladder and non-obstructive urinary retention.A tined lead with 4 stimulation electrodes is placed through the third or fourth sacral foramen and stimulates sacral roots in its vicinity. Since the sacral roots are mixed nerves, it is currently still unknown which nerve fibers are stimulated (autonomic vs somatic, afferent vs efferent) and what the mechanism of action is.

This study examines the involvement of pudendal somatic afferents by measuring somatosensory evoked potentials elicited by stimulation of the pudendal nerve.

Enrollment: 40 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Overactive bladder
• Non-obstructive urinary retention

Exclusion criteria

• Neurogenic disorders (e.g. cerebrovascular accident, spinal cord injury,...)

Trial design

40 participants in 2 patient groups

Successes

Description:

Patients with reduction of symptoms \>50% during the test procedure for sacral neuromodulation.

Treatment:

Diagnostic Test: Somatosensory evoked potentials

Failures

Description:

Patients with reduction of symptoms \<50% during the test procedure for sacral neuromodulation.

Treatment:

Diagnostic Test: Somatosensory evoked potentials