Safety and Effectiveness of Low-flow ECMO Driving by CVVH Machine in Severe NCP

Chinese Academy of Medical Sciences & Peking Union Medical College

Status: Unknown

Conditions: ECMO; COVID-19

Treatments: Device: Low flow ECMO driving by CVVH machine

Study type: Interventional

Funder types: Other

Identifiers

NCT04340414

Low flow-ECMO by CVVH in NCP

Details and patient eligibility

About

assess the safety and effectiveness of using low-flow extracorporeal membrane oxygenation(CO2 removal) driving by CVVH machine in the severe NCP patients

Enrollment: 10 estimated patients

Sex: All

Ages: 14+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 1. NCP with severe acute respiratory distress syndrome with ratio of partial pressure of arterial oxygen over fraction of inspired oxygen (PaO2:FiO2)<150 and PEEP >10cmH2O
• 2. Driving pressure> 20cmH2O
• 3. RR>30bpm
• 4.PaCO2>55cmH2O and/or PH>7.3

Exclusion criteria

• 1. poor venous vascular condition and unavaible for central venous catheter placement

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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10 participants in 1 patient group

NCP patient with severe ARDS and/or high ventilator supported

Experimental group

Description:

The NCP patient with severe ARDS and/or high ventilator supported condition was eligibilitable for enrollment

Treatment:

Device: Low flow ECMO driving by CVVH machine