Safety and Effects of Ramipril Combined With Candesartan

Gachon University Gil Medical Center

Status and phase: Completed; Phase 4

Conditions: Hypertension

Treatments: Drug: ramipril, candesartan

Study type: Interventional

Funder types: Other

Identifiers

NCT00356395

2003-008

Details and patient eligibility

About

we hypothesized that combination therapy has additive beneficial effects to improve endothelial dysfunction and adipocytokine profiles in patients with hypertension.

Full description

Forty patients will be given ramipril 10 mg and placebo, ramipril 10 mg and candesartan 16 mg, or candesartan 16 mg and placebo daily in a randomized, double-blind, placebo-controlled cross-over trial with three treatment arms and two washout periods (each 2 months).

Sex: All

Ages: 35 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with mild to moderate hypertension

Exclusion criteria

• We will exclude patients with severe hypertension, unstable angina, acute myocardial infarction, or renal insufficiency.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind