Safety and Efficacy of Convalescent Plasma Transfusion for Patients With COVID-19 (EPCOvid-1)

Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran

Status and phase: Unknown; Phase 3; Phase 2

Conditions: COVID-19

Treatments: Biological: convalescent plasma

Study type: Interventional

Funder types: Other

Identifiers

NCT04388410

3380

Details and patient eligibility

About

This is a multicenter double blinded study to evaluate the efficacy and safety of convalescent plasma from COVID-19 recovered individuals to treat hospitalized patients with severe COVID-19 disease. The study will enroll 410 subjects who will be randomized 1:1 to receive convalescent plasma or normal saline solution in a blinded manner. The primary endpoint will be improvement on the 8 point WHO scale over 28 days. Mortality at day 28 will be a secondary endpoint. An interim analysis will be done when 224 patients have completed their follow up to assess safety and to indicate continuation or stopping of the study, based on safety and efficacy observed.

Full description

A total of 410 patients with COVID 19 who fulfill inclusion criteria will be invited to receive:

Human convalescent plasma from recovered patients in two infusions of 200 ml separated with 24 to 72 hours or Normal saline solution in a similar plasma bag. Both products will be covered in an identical material to avoid identification of the infused product.

Primary endpoint:

Improvement on the 8 point WHO scale over 28 days.

Secondary endpoints.

Mortality at day 28

• Presence of antibodies against SARS-CoV-2 in serum on days 0, 3, 7, 14, 21 y 28 after plasma administration, as long as the patient remains in the hospital.
• Disease progression to a worse stage compared to the baseline on admission to the study according to SOFA scale.
• Disease progression to a worse stage defined as worsening in at least two categories in the OMS disease scale on different timelines in comparison to baseline on admission to the study
• Number of hours on mechanical ventilation in those who enter the study on mechanical ventilation.
• Number of days with fever defined as temperature >38°C on at least one occasion during the day

Inclusion criteria:

1. Adults older than 18 years.
2. Confirmed SARS-CoV2 infection
3. Patient hospitalized for COVID 19
4. Severe disease or risk for severe disease
5. Informed consent from patient or responsible person.

Exclusion criteria

1. History of allergic reactions to blood products
2. SOFA scale >12 points
3. Absolute contraindication for administration of plasma
4. Participation in other blinded clinical trial
5. Projected life expectancy less than 3 months
6. Any condition perceived by the investigator as not appropriate for participation of the patient in the trial.

Enrollment: 410 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Adults 18 years of age and older.
2. Confirmed SARS-CoV2 infection
3. Hospitalized for COVID 19
4. Severe disease or risk for severe disease
5. Informed consent from patient or responsible person.

Exclusion criteria

1. History of allergic reactions to blood products
2. SOFA scale >12 points
3. Absolute contraindication for administration of plasma
4. Participation in other blinded clinical trial
5. Projected life expectancy less than 3 months
6. Any condition perceived by the investigator as not appropriate for participation of the patient in the trial.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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410 participants in 2 patient groups, including a placebo group

convalescent plasma

Experimental group

Description:

Convalescent plasma obtained from volunteers who have recovered from COVID 19. Enclosed with a similar material as the control

Treatment:

Biological: convalescent plasma

Normal saline

Placebo Comparator group

Description:

Normal saline solution in 200 ml plasma bags enclosed with with a similar material as the plasma

Treatment:

Biological: convalescent plasma