Safety and Efficacy of Heparin Dosing Score Protocol for Polymyxin-B Hemoperfusion

National Taiwan University

Status: Unknown

Conditions: Polymyxin B Hemoperfusion; Septic Shock

Study type: Observational

Funder types: Other

Identifiers

NCT03177330

201704033RIND

Details and patient eligibility

About

Polymyxin B hemoperfusion (PMX-HP) is mainly used to remove endotoxins in septic shock patients with intra-abdominal infections. Because of the concerns of postoperative bleeding, physicians may hesitate to use anticoagulation in patients with septic shock within a few hours after an abdominal operation. We developed a heparin dosing score protocol for heparin dosage adjustment. The purpose of the study is to examine the safety and efficacy of the heparin dosing score protocol.

Enrollment: 30 estimated patients

Sex: All

Ages: 20 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• intra-abdominal septic shock patients or documented Gram-negative bacterial septic shock patients who received polymyxin-B hemoperfusion in National Taiwan University Hospital during October 2013-December 2016

Exclusion criteria

• pregnant woman
• patients with do-not-resuscitate declaration
• uncontrolled bleeding within 24hr