Safety and Efficacy of IDEC-114 in the Treatment of Non-Hodgkin's Lymphoma

Biogen logo

Biogen

Status and phase

Completed
Phase 2
Phase 1

Conditions

Non-Hodgkin's Lymphoma

Treatments

Drug: IDEC-114

Study type

Interventional

Funder types

Industry

Identifiers

NCT00575068
114-20

Details and patient eligibility

About

The purpose of this study is to determine whether anti-CD80 monoclonal antibody (IDEC-114) is effective in the treatment of follicular B-cell non-Hodgkin's lymphoma. This drug has never been studied in patients with lymphoma, however, it has been studied in psoriasis patients at various dose levels and schedules.

Enrollment

42 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Histologically confirmed follicular lymphoma that has relapsed or has failed primary therapy
  • Progressive disease requiring further treatment
  • Bidimensionally measurable disease
  • Acceptable hematologic status
  • Prestudy WHO performance status of 0, 1, or 2
  • Expected survival of >/= 3 months
  • Patients with reproductive potential must follow accepted birth control methods during treatment and for 3 months after completion of treatment
  • Female patients must not be pregnant or lactating
  • Recovered fully from any significant toxicity associated with prior surgery, radiation treatments, chemotherapy, biological therapy, ABMT, or investigational drugs

Exclusion criteria

  • Cancer radiotherapy, biological therapy, or chemotherapy within 3 weeks of first scheduled treatment (6 weeks if nitrosourea or mitomycin-C)
  • Prednisone or other immunosuppressive therapy within 3 weeks of first scheduled treatment
  • Prior antibody therapy for lymphoma (including radioimmunotherapy) within 6 months prior to first scheduled treatment
  • Previous exposure to IDEC-114 or any anti-CD80 antibody
  • ABMT within 6 months prior to first scheduled treatment
  • Abnormal liver function
  • Abnormal renal function
  • Presence of chronic lymphocytic leukemia (CLL)
  • Presence of CNS lymphoma
  • Presence of HIV infection or AIDS
  • Prior diagnosis of aggressive non-Hodgkin's lymphoma or mantle-cell lymphoma
  • Another primary malignancy (other than squamous cell and basal cell carcinoma of the skin, in situ carcinoma of the cervix, or treated prostate cancer with a stable PSA) for which the patient has not been disease-free for at least 3 years
  • Serious nonmalignant disease which would compromise protocol objectives in the opinion of the investigator and/or the sponsor
  • New York Heart Association Class III or IV cardiac disease or myocardial infarction within 6 months prior to first scheduled treatment
  • Major surgery, other than diagnostic surgery, within 4 weeks prior to first scheduled treatment
  • Pleural invasion and/or effusion with positive cytology for lymphoma
  • Peritoneal invasion and/or ascites with positive cytology for lymphoma

Trial design

Primary purpose

Treatment

Allocation

Non-Randomized

Interventional model

Single Group Assignment

Masking

None (Open label)

42 participants in 1 patient group

1
Experimental group
Treatment:
Drug: IDEC-114

Trial contacts and locations

0

Loading...

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location

Resources

© Copyright 2024 Veeva Systems