Safety and Efficacy of Obatoclax Mesylate (GX15-070MS)for the Treatment of Myelodysplastic Syndromes (MDS)

Gemin X

Status and phase

Completed

Phase 2

Conditions

Myelodysplastic Syndromes

Treatments

Drug: Obatoclax mesylate (GX15-070MS)

Study type

Interventional

Funder types

Industry

Identifiers

NCT00413114

GEM013

Details and patient eligibility

About

Defects in the apoptotic process can lead to the onset of cancer by allowing cells to grow unchecked when an oncogeneic signal is present. Obatoclax is designed to restore apoptosis through inhibition of the Bcl-2 family of proteins, thereby reinstating the natural process of cell death that is often inhibited in cancer cells.

This is a multi-center, open-label, Phase II study of obatoclax administered in 2-week cycles to patients with previously-untreated Myelodysplastic Syndromes with anemia and/or thrombocytopenia. Treatment may be administered on an outpatient basis. No investigational or commercial agents or therapies other than those described herein may be administered with the intent to treat the patient's malignancy. Supportive care measures including those directed at controlling symptoms resulting from Myelodysplastic Syndromes are allowed

Enrollment

24 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Pathological confirmation of Myelodysplastic Syndromes (MDS)
Patients must have had no prior systemic therapy
Must have normal organ functions
Must have the ability to understand and willingness to sign a written informed consent form

Exclusion criteria

Must not be a result of prior chemotherapy and/or radiotherapy for another malignancy
No other agents or therapies administered in the intent to treat
Uncontrolled, intercurrent illness
Pregnant women and women who are breast feeding