Safety and Efficacy of Stem Cell Transplantation for Treatment of Liver Cirrhosis

General Hospital of Chinese Armed Police Forces

Status and phase: Unknown; Phase 3; Phase 2

Conditions: Other Surgical Procedures

Treatments: Procedure: stem cell transplantation through interventional procedures

Study type: Interventional

Funder types: Other

Identifiers

NCT01491165

2011-12-07 liver cirrhosis

Details and patient eligibility

About

Mainstream of current treatment of liver cirrhosis is liver transplantation, but there are high cost, risk and immune rejection and other issues. Umbilical cord mesenchyma stem cell with self-and directed differentiation capacity can effectively rescue experimental liver failure and contribute to liver regeneration, which suggests the feasibility of stem cell transplantation therapy. In this study, the safety and efficacy of umbilical cord mesenchyma stem cell transplantation through interventional procedures in patients liver cirrhosis will be evaluated.

Full description

This study included three research centers, each center were carried out 25 cases of liver cirrhosis in patients with stem cell transplantation. All the selection and exclusion criteria are same, data summary and analysis will be complete by the epidemiological commissioner.

Enrollment: 75 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of liver cirrhosis;
• Without hepatic encephalopathy;
• No ascites or have easily dissipated ascites;
• Value of bilirubin is less than 100;
• Value of albumin is greater than 16 g / L;
• Prothrombin time is less than 21 seconds;

Exclusion criteria

• Severe cardiovascular disease, and immunocompromised patients;
• Patients with localized lesions affecting graft infection;
• Coagulation disorders;
• Liver nodules more than 2cm or Liver cancer

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

75 participants in 1 patient group

stem cell transplantation therapy

Experimental group

Description:

umbilical cord mesenchyma stem cell transplantation through interventional procedures do in liver cirrhosis patients.

Treatment:

Procedure: stem cell transplantation through interventional procedures