Safety and Efficacy of Urtica Dioica Cataplasm in the Management of Osgood-Schlatter Disease in Young Athletes

Faculty of Medicine, Sousse

Status: Not yet enrolling

Conditions: Osgood-Schlatter Disease

Treatments: Other: Urtica dioica cataplasm; Drug: Vitamin D; Other: Placebo; Behavioral: Resting conditions

Study type: Interventional

Funder types: Other

Identifiers

NCT07096037

UDC-OSD-2025

Details and patient eligibility

About

The primary objective of this clinical trial is to evaluate the efficacy and safety of a topical Urtica dioica cataplasm in managing knee pain and functional limitations in athletic children diagnosed with Osgood-Schlatter Disease. Efficacy will be assessed through changes in knee pain using the Visual Analog Scale (VAS) and functional outcomes using the Knee Injury and Osteoarthritis Outcome Score (KOOS). Three groups will be tested:

• UDC Group: topical application of Urtica dioica cataplasm
• Standard Care Group: oral vitamin D supplementation and physical rest
• Placebo Group: topical application of a placebo cataplasm using Beta vulgaris subsp. cicla

Enrollment: 90 estimated patients

Sex: Male

Ages: 7 to 15 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Healthy male children between 7 and 15 years of age
• Active in regular sports practice (e.g., football)
• Clinically confirmed diagnosis of OSD

Exclusion criteria

• Known allergy to Urtica dioica
• Presence of dermatological conditions or lesions on the knees
• Recent use of anti-inflammatory medications
• History of immune or chronic inflammatory diseases
• Diagnosis of any other bone disorder

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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90 participants in 3 patient groups, including a placebo group

Urtica dioica cataplasm

Experimental group

Description:

Topical application of Urtica dioica cataplasm

Treatment:

Other: Urtica dioica cataplasm

Standard Care Group

Active Comparator group

Description:

Oral vitamin D supplementation and physical rest

Treatment:

Behavioral: Resting conditions

Drug: Vitamin D

Placebo

Placebo Comparator group

Description:

Topical application of a placebo cataplasm

Treatment:

Other: Placebo