Safety and Efficacy Study of RTS,S AS02A/AS01B Vaccine to Prevent Malaria

United States Army Medical Research and Development Command (USAMRDC)

Status and phase: Completed; Phase 2; Phase 1

Conditions: Malaria

Treatments: Biological: RTS,S with AS02A/AS01B adjuvant

Study type: Interventional

Funder types: Other U.S. Federal agency; Industry

Identifiers

NCT00075049

WRAIR 1032

HSRRB A-12227

257049/027

Details and patient eligibility

About

This is a double blinded study where 2 test vaccines will be evaluated to see if they protect persons who have never had malaria against malaria infection when bitten by mosquitoes.

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Be in good general health
• Be able to participate for 4-15 months

Exclusion criteria

• Pregnant or planning pregnancy
• History of malaria or exposure to malaria in past 12 months
• Received an investigational malaria vaccine
• Past history of allergic reaction to previous immunization
• Positive blood tests for HIV and specific types of hepatitis

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Double Blind