Safety and Feasibility of High-intensity Interval Training Program in CF Patients (ITHI)

Fondation Ildys

Status

Completed

Conditions

Cystic Fibrosis

Treatments

Other: Interval Training Hight Intensity Program

Study type

Interventional

Funder types

Other

Identifiers

NCT04888767

ILDYS-ISC2-2020-002

ID-RCB (Other Identifier)

Details and patient eligibility

About

This study compare an usual training program (in continuous endurance) with an ITHI program over a period of 3 weeks, in France. The aim is to evaluate the safety and feasibility of this type of program in CF adults, and also more specifically, in subgroups:

patients divided according to the severity of their FEV1 ; patients treated with modulating CFTR canal therapy ; diabetic patients on insulin ; undernourished patients.

Full description

Objectives Studies have shown good tolerance of High Intensity Interval Training (ITHI) in healthy people or in COPD with similar results obtained with continuous training regimen, but with less shortness of breath and muscle fatigue, greater pleasure and a positive impact on glycemia. Research in CF is still scarce.

We propose to compare our usual training program (in continuous endurance) with an ITHI program over a period of 3 weeks, corresponding to the length of the rehabilitation stay in France. Our aim is to evaluate the safety and feasibility of this type of program in CF adults, and also more specifically, in subgroups:

patients divided according to the severity of their FEV1
patients treated with modulating CFTR canal therapy
diabetic patients on insulin
undernourished patients (BMI ≤ 18.5)

Methodology

Bicentric (Roscoff-Giens); prospective; opened; randomized; controlled
Rehabilitation stay in hospitalization with 18 days of training, on an ergometer, supervised by an APA teacher or a physiotherapist
- Control group: 5 times / week; continuous work 20 to 30 min; around the 1st aerobic ventilation threshold
- Intervention group: 2 times / week: maintenance sessions + 3 times / week: IHTI sessions - alternating 30s work / 30s rest repeated 6 times; at 60% of the maximum heart rate at the 1st session then increase as fast and large as possible
Distribution of the 100 patients included in a 1: 1 ratio
Examinations / Questionnaires in current practice: medical consultation; quality of life (CFQ-R); anxiety-depression (HAD); "Starfish" (Feelings linked to physical activity) ; blood sugar (Freestyle); impedance measurement; respiratory capacity measurement ; Voluntary Driving Force; walk test (TM6); dyspnea scale (Borg)
Study-specific measures: MDP (Multidimensional Profile of Dyspnea) and PACES (Physical Activity Enjoyment Scale) scales

Expected results

Through this pilot study we are expecting to answer several questions:

are the safety and tolerance of an ITHI program at least equal if not better than that of a "classic" training?
what about the most severe patients?
could patients on modulator have ITHI training (treatment likely to increase creatine kinase - muscle enzyme -)?
are diabetic patients more at risk of hypoglycaemia during an ITHI compared to traditional training?
could undernourished patients participate in ITHI regimen?

Perspective If ITHI appears to be safe and well tolerated, it could be integrated into "classic" rehabilitation programs and represent an interesting alternative, depending on the profile of each patient. The effectiveness of the ITHI program will also be discussed by evaluating several parameters, including 6mn walking distance test (6MWD). The emerging trends would allow some recommendations and more in-depth studies.

Enrollment

62 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

men and women aged over 18 years of age on the date of informed consent
diagnosed CF patients
not transplanted and not on the transplant waiting list
able to participate in the proposed training programs (especially without cardiac contraindication)
able to understand and respect the protocol and its requirement
who signed the consent prior to any other procedure protocol

Exclusion criteria

major patients under guardianship / curatorship / legal protection
pregnant patients
dialysis patients
patients with a severe exacerbation at the time of inclusion
patients for whom a new modulating treatment (eg.: Kaftrio®, Kalydeco®, Symkevi®, etc.) has been implemented in the 4 weeks preceding inclusion
patients with pulmonary arterial hypertension (≥ 25 mmHg)
patients unable to complete the entire program