Safety and Feasibility of Reversible Induction Strategy

Shanghai Jiao Tong University

Status: Unknown

Conditions: Patients With Uncertain Difficult Airway; Gastric Cancer; Colon Cancer; Prostatic Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT04434963

RenjiH6502

Details and patient eligibility

About

This study would explore the safety and feasibility of a reversible induction strategy for uncertain difficult airway. This reversible induction strategy would include high flow nasal canular oxygenation support, short-term effect anesthetic including Propofol and Remifentanil for sedation and analgesia and Sugammadex would be used for reverse the muscle relaxant.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• >18 years old,<65 years old
• Signed informed consent
• Undergoing selective operation （ time of operation is over two hours）
• ASA classification I-II
• Mallampati classification 3-4
• suspicious difficult airway, but the anesthetists decide to try to rapid induction

Exclusion criteria

• Patients with several dysfunctions of liver, kidney or heart)
• Patients with a full stomach or have other risk factors of reflux aspiration
• Any medicine was taken before surgery, which might enhance or mitigate the effects of muscle relaxant
• Infection of the mouth or nose
• Allergy history of any medicine which would be used in this study
• Pregnant and lactating women
• Patients with neuromuscular disease