Safety and Immunogenicity of CJ-50300

Seoul National University logo

Seoul National University

Status and phase

Completed
Phase 1

Conditions

Smallpox

Treatments

Biological: cell-culture derived smallpox vaccine

Study type

Interventional

Funder types

Other
Industry

Identifiers

NCT00336635
CJ_SPX_101

Details and patient eligibility

About

The currently available stock of smallpox vaccine would be insufficient in the face of an incident of smallpox attack. Thus, new manufacturing methods for smallpox vaccine is urgently needed because previous manufacturing methods using calf lymph are no longer acceptable in the view of current standards. Recently, CJ corporation in Republic of Korea has developed cell-culture derived smallpox vaccine (CJ-50300) which was manufactured by infecting MRC-5 cells. The aim of this phase 1 clinical trial were to assess safety, reactogenicity, and immunogenicity of CJ-50300.

Sex

All

Ages

20 to 28 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  1. Healthy Korean male and female subjects between 20 and 28 years of age at the time of screening visit.
  2. Willing to participate and have signed the informed consent form
  3. In good general health, without clinically skin diseases history, physical examination or laboratory test results
  4. Hematocrit >33% for women; >38% for men
  5. White cell count 3,300-12,000/mm3
  6. Total lymphocyte count > 800 cells/mm3

Exclusion criteria

  1. Diseases or conditions that cause immunodeficiency (For examples; HIV AIDS, leukemia, lymphoma, generalized malignancy, agammaglobulinemia, history of transplantation, therapy with alkylating agents, antimetabolites, radiation, or oral or parenteral corticosteroids).
  2. In close physical contact (household or at work) with an individual who has the diseases or conditions that cause immunodeficiency
  3. history or present of eczema or atopic dermatitis
  4. Allergy or sensitivity to any known components of vaccine or other medicines
  5. In close physical contact (household or at work) with an individual who has acute or chronic skin conditions such as dermatitis, exfoliative dermatitis
  6. Subjects with inflammatory ophthalmic disease requiring steroid therapy
  7. Subjects who are planning for blood donations
  8. Autoimmune disease such as lupus erythematosus
  9. Subjects who work in medical institution
  10. Household contacts with women who are pregnant or breast-feeding
  11. Female Subjects who are pregnant or breast-feeding and have positive result by serum pregnancy test or urine pregnancy test, or do not using approved contraceptives such as sterilization, contraceptive ring injectable, combined oral contraceptive pills and barrier contraceptive, combined hormone-based therapy, contraceptive cream, contraceptive jelly, diaphragm or condoms
  12. Subjects household member <1 year old or work with children <1 year old
  13. Subjects with a known history of Cardiac disease or have three or more of the following risk factors: hyperpiesia, obesity, hyperlipidemia, glucosuria, sclerosis, cerebral arteriosclerosis
  14. Receipt of immunoglobulin and steroid within 14 days of vaccination
  15. Receipt of investigational research agents within 120 days of vaccination
  16. HBsAg seropositive
  17. HCV antibody seropositive
  18. HIV seropositive
  19. Subjects having fever (oral temperature > 38℃) or severe nutrition disorder
  20. Blood donation within 12 weeks in advance screening visit
  21. Subject who are not suitable to participate in study according to invesigator's judgement

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Single Group Assignment

Masking

Double Blind

Trial contacts and locations

1

Loading...

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2024 Veeva Systems