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About
This is a two part introductory clinical trial with MK-5478. Part I will evaluate the safety, tolerability and pharmacokinetics and pharmacodynamics of MK-5478 in young, healthy males. Part II will evaluate the safety, tolerability and pharmacodynamic effects of MK-5478 in participants with hypertension. The primary hypothesis is that single oral doses of MK-5478 are sufficiently safe and well tolerated.
Enrollment
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Inclusion criteria
Part I:
Part II:
Exclusion criteria
Part I and Part II:
Primary purpose
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Interventional model
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20 participants in 10 patient groups
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Data sourced from clinicaltrials.gov
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