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Safety and Tolerability Study of PCI-32765 in B Cell Lymphoma and Chronic Lymphocytic Leukemia

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Pharmacyclics

Status and phase

Completed
Phase 2

Conditions

Diffuse Well-differentiated Lymphocytic Lymphoma
Waldenstrom Macroglobulinemia
Non-Hodgkin's Lymphoma
B Cell Lymphoma
Mantle Cell Lymphoma
Follicular Lymphoma
Small Lymphocytic Lymphoma
B-cell Chronic Lymphocytic Leukemia
Burkitt Lymphoma
B-Cell Diffuse Lymphoma

Treatments

Drug: PCI-32765

Study type

Interventional

Funder types

Industry

Identifiers

NCT01109069
PCI-32765 (Other Identifier)
PCYC-1103-CA

Details and patient eligibility

About

The purpose of this study is to determine the long-term safety of a fixed-dose, daily regimen of PCI-32765 PO in subjects with B cell lymphoma or chronic lymphocytic leukemia/small lymphocytic leukemia (CLL/SLL).

Enrollment

199 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Men and women with recurrent surface immunoglobulin positive B cell non-Hodgkin's lymphoma (NHL) according to WHO classification (including, but not limited to, CLL/SLL, Waldenström's macroglobulinemia [WM], mantle cell lymphoma [MCL], and diffuse large B cell lymphoma [DLBCL) who have met requirements for roll over from their parent protocol and want to continue study drug.
  • Female subjects of childbearing potential must have a negative serum or urine pregnancy test within 3 days of the first dose of study drug and agree to use dual methods of contraception during the study and for 1 month following the last dose with study drug. Post menopausal females (>45 years old and without menses for >1 year) and surgically sterilized females are exempt from this criterion.
  • Male subjects must use an effective barrier method of contraception during the study and for 3 months following the last dose if sexually active with a female of childbearing potential.
  • Willing and able to participate in all required evaluations and procedures in this study protocol including swallowing capsules without difficulty
  • Ability to understand the purpose and risks of the study and provide signed and dated informed consent and authorization to use protected health information (in accordance with national and local patient privacy regulations).

Exclusion criteria

  • A life-threatening illness, medical condition or organ system dysfunction which, in the investigator's opinion, could compromise the subject's safety, interfere with the absorption or metabolism of PCI-32765 PO, or put the study outcomes at undue risk
  • Known history of Human Immunodeficiency Virus (HIV) or active infection with Hepatitis C Virus (HCV) or Hepatitis B Virus (HBV) or any uncontrolled active systemic infection.
  • Lactating or pregnant

Trial design

Primary purpose

Treatment

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

199 participants in 1 patient group

PCI-32765
Experimental group
Treatment:
Drug: PCI-32765

Trial documents
1

Trial contacts and locations

16

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Data sourced from clinicaltrials.gov

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