Safety Evaluation of Propofol Sedation for Magnetic Resonance Imaging in Pediatric Patients

CHU Brugmann University Hospital

Status

Completed

Conditions

Anesthesia; Adverse Effect

Sedation Complication

Propofol Adverse Reaction

Multiparametric Magnetic Resonance Imaging

Treatments

Drug: Propofol

Study type

Observational

Funder types

Other

Identifiers

NCT04455776

CHUB_PEDIRM

Details and patient eligibility

About

Propofol is often used for sedation in children undergoing magnetic resonance imaging. The investigators will perform a chart review of 4 month of activity (about 100 cases) and review the incidence and severity of adverse events of this sedation technique.

Full description

Magnetic resonance imaging in children, especially under 6 years of age, is often performed under sedation. Propofol is a common drug used in this settings. In our institution, sedation is most often done by a propofol bolus of 2-5 mg/kg in order to reach a deep level of sedation as defined by Coté et al. If judged necessary by the attending anaesthesiologist, a additional propofol bolus of 0.5-1 mg/kg may be given. For longer lasting exams, the attending anaesthesiologist can chose to use a continuous infusion of propofol. The investigators will review the charts of 4 month of magnetic resonance imaging, which will give us a cohort of about 100 patients. Baseline characteristics, detailed sedation technique used will be recorded. Adverse events defined as:

Oxygen desaturation measured by transcutaneous oximetry SpO2≤94%
hypercapnia measure by end-tidal CO2 >45 mm Hg
movement of the patient

Assuming a non-normal distribution (tested by a Kolmogorov-Smirnov test), variables will be reported as median and interquartile range. Statistical tests will be done by non-parametric tests, Mann Whitney U. Non continuous variables will be analyzed by a Chi-square test.

Enrollment

99 patients

Sex

All

Ages

Under 16 years old

Volunteers

No Healthy Volunteers

Inclusion criteria