Safety of Ibritumomab Tiuxetan (Zevalin®) in Combination With a Fludarabine-based Reduced Intensity Conditioning (RIC) Regimen (ZEVALLO 2007)

University Hospital of Bordeaux

Status and phase

Completed

Phase 2

Conditions

Mantle Cell Lymphoma

Diffuse Large B-Cell Lymphoma

Treatments

Drug: Ibritumomab Tiuxetan (Zevalin)

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT00607854

CHUBX 2007/11

Details and patient eligibility

About

The purpose of this study is to evaluate the safety and efficacy of Zevalin® in a Reduced Intensity Conditioning regimen followed by allogenic stem cell support in patients with aggressive lymphomas who are responsive to a salvage chemotherapy regimen.

Full description

The benefit of Zevalin® in the setting of autologous stem cell transplantation has been largely reported. The addition of Zevalin® to a fludarabine-based Reduced Intensity Conditioning regimen has been already evaluated in the setting of allo-SCT and the results reported so far seem to be promising without an overwhelming toxicity neither a delayed hematologic recovery. The assumption that the addition of Zevalin® to the conditioning regimen might improve lymphoma control and the demonstration that nucleoside analogs such as fludarabine synergize optimally with RIT led us to conduct this trial using the following preparative regimen: rituximab 250 mg/m² on days -21 and -14, Zevalin® 0,4 mCi/Kg body weight on day -14, fludarabine 30 mg/m² intravenously from days -6 to -2, Busulfan orally (4 mg/Kg body weight) or intravenously (0,8 mg/Kg body weight) on days -5 and -4 and ATG (Thymoglobulin®) 2,5 mg/Kg body weight intravenously on day -1. Cyclosporine A is administered at 2 or 3 mg/Kg body weight from day -1 to day 28 than followed by a dose reduction.

Patients are followed from the beginning of the RIC regimen until day 365 for primary and secondary objectives of the study than on a regular basis depending on the practice of each centre. The evaluation includes physical examination (performance status, hematologic assessment, acute and chronic GVH disease), biologic tests (blood screening for blood count, renal and hepatic function, B and T-cell recovery, chimerism analysis, response assessment) and complementary examinations (marrow biopsies, tomography scan, positron emission tomography, ...).

Enrollment

31 patients

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age ≥ 18 and ≤ 65
Patients with this lymphoma:
1. CD20 positive diffuse large B-cell lymphoma in relapse or refractory after two prior regimens or after one regimen including autologous stem cell transplantation, or
2. CD20 positive mantle-cell lymphoma in relapse or refractory after two prior regimens or after one regimen including autologous stem cell transplantation or
3. Other CD20 positive aggressive lymphoma for which an indication of allograft is selected (Burkitt lymphoma, lymphoblastic lymphoma, intra-vascular lymphoma.....) or
4. Low grade lymphoma CD20 positive (follicular lymphoma, marginal zone lymphoma) in histological processing or
5. Low grade lymphoma CD20 positive for which an indication of allograft is selected
And sensitive to relapse's treatment
HLA-matched related or unrelated donor 10/10 or 9/10 with C or DQ mismatch without contra-indication for stem cell mobilization
ECOG (Eastern Cooperative Oncology Group) < 2
Having or not received previously rituximab
With a chemosensitive relapse NHL (at least partial response > 50% as defined with cheson criteria (See appendix 5)
Eligible for an allogenic transplant
With a signed informed consent (obtained on the screening day at the latest and before any investigation)
Patient affiliated to or beneficiary of the National Health Service

Exclusion criteria

Patient allografted previously
History of cancer
Patient with HIV or HCV positive serology and requiring treatment
Childbearing or child breastfeeding women
Women who are pregnant or nursing, or man, in the absence of effective contraception during treatment and up to 12 months after stopping treatment
Any contraindication to allogenic stem cell transplantation:
Cardiac insufficiency (ejection fraction < 50% by echocardiography)
Respiratory insufficiency defined as DLCO below 50% of the theoretical value
Renal failure defined as creatinin clearance < 30 ml/mn
Hepatic failure defined as a 2-fold increase of bilirubin or transaminases except if due to the lymphoma
Known hypersensitivity to murine antibodies and other proteins, the active ingredients or any of the ingredients of the products under review
Patient under the protection of justice