Safety of Polyphenon E in Multiple Sclerosis Pilot Study

Louisiana State University

Status and phase

Completed

Phase 1

Conditions

Multiple Sclerosis

Treatments

Drug: Polyphenon E

Study type

Interventional

Funder types

Other

NIH

Identifiers

NCT00836719

1K23AT004433-01 (U.S. NIH Grant/Contract)

K23AT004433-01 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

This study is an open label 6 month study. All subjects will be treated with Polyphenon E (400 mg EGCG twice a day) for six months. The main outcome of this pilot phase will be safety. Secondary outcomes are the change in NAA levels over 6 months as measured by MR-spectroscopy. NAA levels are a marker of neuronal function. We think that Polyphenon E will protect neurons and thus increase NAA levels.

Full description

Additional clinical data include changes in EDSS, MS functional composite and cognitive testing.

Enrollment

10 patients

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Diagnosis of MS by McDonald criteria
Relapsing-remitting MS or secondary progressive MS
Stable therapy with Copaxone, for at least six months prior to inclusion in the study or no therapy for six months in subjects refusing therapy.
EDSS Score less than or equal to 6.5 (able to walk about 20 meters without resting)
Ages 18-60.
Leukocytes ≥3,000/µL
Absolute neutrophil count ≥1,500/µL
Platelets ≥100,000/µL
Total bilirubin ≤local upper limit of normal
normal AST (SGOT) ALT (SGPT)
normal serum Creatinine
women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation.
Ability to understand and the willingness to sign a written informed consent document.
Willing to drink at most one cup of black tea and two cups of coffee per day, and abstain from drinking green tea or taking supplements containing green tea or green tea compounds, for the duration of the investigation.

Exclusion criteria

MS relapse within the 30 days prior to enrollment.
A primary progressive form of MS.
Previous treatment prior to study entry as follows: complete radiation ablation of the bone marrow or anti-CD4 antibody treatment (Campath) at any time; mitoxantrone, cyclophosphamide, cyclosporin, Natalizumab or other immunomodulatory or immunosuppressant therapies except for Copaxone or methylprednisone for relapses within prior nine months.
History of renal or liver disease.
Consumption of green tea or supplements containing green tea or tea extract within 30 days prior to enrollment.
Participants may not participate in any other clinical trial involving investigational agents during the study, or within six months prior to enrolling in the study.
history of allergic reactions attributed to compounds of similar chemical or biologic composition to Polyphenon E, tea, or any of the inactive ingredients present in the active or placebo capsules, including gelatin.
history of allergic reactions to gadolinium or any other condition contraindicated for MRI.
Uncontrolled, clinically-relevant active illness (aside from MS) including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
Any condition which would make the subject, in the opinion of the investigator, unsuitable for the study.
Inability to complete the baseline MRI scan.
Pregnant or breastfeeding women.