Safety of Pregnancy in BRCA Mutated Breast Cancer Patients

Free University of Brussels (ULB)

Status: Completed

Conditions: Breast Cancer

Treatments: Other: Clinical outcomes

Study type: Observational

Funder types: Other

Identifiers

NCT03673306

IJB-BRCAPreg-CE2630

Details and patient eligibility

About

The present study aims at refining the understanding of the effect of pregnancy on breast cancer outcomes in the specific population of BRCA mutated patients with known history of breast cancer.

Enrollment: 4,732 patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of invasive breast cancer between January 2000 and December 2020;
• Breast cancer diagnosis at the age of ≤ 40 years;
• Known presence of germline BRCA mutation.

Exclusion criteria

• Known BRCA mutation with no diagnosis of invasive breast cancer;
• Diagnosis of ovarian cancer or other malignancies with no history of invasive breast cancer;
• Diagnosis of hereditary or familiar invasive breast cancer without BRCA mutation or with BRCA genes not tested;
• Diagnosis of invasive breast cancer with germline BRCA variants of unknown significance.

Trial design

4,732 participants in 2 patient groups

Pregnant cohort

Description:

Women with one or more pregnancies any time after breast cancer diagnosis

Treatment:

Other: Clinical outcomes

Non-pregnant cohort

Description:

Women with no subsequent pregnancies after breast cancer diagnosis

Treatment:

Other: Clinical outcomes