Safety Study of Conventional Versus Micropulse Transscleral Cyclophotocoagulation in Treating End-Stage Glaucoma

National University Health System (NUHS)

Status and phase

Unknown

Phase 2

Phase 1

Conditions

Advanced Glaucoma

Refractory Glaucoma

Treatments

Procedure: Micropulse Transscleral Cyclophotocoagulation

Procedure: Conventional Transscleral Cyclophotocoagulation

Study type

Interventional

Funder types

Other

Identifiers

NCT00349414

DSRB Reference Code: A/06/164

Details and patient eligibility

About

The aim of this study is to compare the safety and efficacy of conventional and micropulse transscleral diode laser in the treatment of end-stage glaucoma.

Full description

End-stage glaucoma is difficult to treat, and it may sometimes be unresponsive to surgery or medications. A common treatment is the conventional transscleral cyclophotocoagulaion, but it has various side effects. This study specifically aims to compare the intraocular pressure (IOP) lowering effects and the incidence of complications such as hypotony, phthisis, sympathetic ophthalmia, surface conjunctival burns, bulbar conjunctival swelling, decompensation of corneal grafts, hyphema and vitreous hemorrhage, in conventional and the newer micropulse transscleral cyclophotocoagulation.The hypothesis is that the micropulse transscleral cyclophotocoagulation will be as good or better than the conventional transscleral cyclophotocoagulation, with less complications.

Enrollment

70 estimated patients

Sex

All

Ages

22+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

· More than 21 years old
- Advanced glaucoma refractory to maximum tolerated medical and surgical treatment
- Visual acuity worse than 6/60
- Poor candidates for additional filtration surgery

Exclusion criteria