Safety Study of Non-invasive Ventilation Versus High-flow Oxygen in Patients With Hypoxemic Respiratory Failure Undergoing Fiberoptic Bronchoscopy.

Universitätsklinikum Hamburg-Eppendorf

Status: Completed

Conditions: Respiratory Failure

Treatments: Procedure: fiberoptic bronchoscopy; Device: high-flow oxygen; Device: non-invasive ventilation

Study type: Interventional

Funder types: Other

Identifiers

NCT01870765

PV-4442

Details and patient eligibility

About

Bronchoscopy with broncho-alveolar lavage is a diagnostic tool in patients with pneumonia. Especially patients with acute or chronic pulmonary diseases are at risk of respiratory failure during or after bronchoscopy. It is known that in these cases bronchoscopy can be performed safely using non-invasive ventilation. It seems probable that high-flow oxygen, which is used in the treatment of patients with hypoxemic respiratory failure, is equally effective in preventing the development of respiratory failure during fiberoptic bronchoscopy while improving patient comfort. In this prospective randomised study the safety of high-flow oxygen is compared with non-invasive ventilation in patients with hypoxemic respiratory failure undergoing fiberoptic bronchoscopy.

Enrollment: 40 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients treated in an intensive care unit
• indication for bronchoscopy and broncho-alveolar lavage
• presence of hypoxemic (SaO2/fraction of inspired oxygen(FiO2): 300 or less) and/or hypercapnic respiratory failure

Exclusion criteria

• patients already on invasive ventilation
• indication for intubation
• blocked nasopharynx
• contraindications for non-invasive ventilation or high-flow oxygen

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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40 participants in 2 patient groups

non-invasive ventilation

Active Comparator group

Description:

Performance of bronchoscopy during non-invasive ventilation.

Treatment:

Procedure: fiberoptic bronchoscopy

Device: non-invasive ventilation

high-flow oxygen

Experimental group

Description:

Performance of bronchoscopy during high-flow oxygen therapy.

Treatment:

Device: high-flow oxygen

Procedure: fiberoptic bronchoscopy