Safety, Tolerability and Efficacy of Disulfiram and Copper Gluconate in Recurrent Glioblastoma

Cantex Pharmaceuticals

Status and phase

Completed

Phase 2

Conditions

Recurrent Glioblastoma

Treatments

Drug: Temozolomide (TMZ)

Drug: Disulfiram/Copper

Study type

Interventional

Funder types

Industry

Identifiers

NCT03034135

CAN-201

Details and patient eligibility

About

This study of DSF-Cu in combination with TMZ for recurrent GBM will evaluate the antitumor effect in patients who have recurrent GBM. Patients will take DSF-Cu daily during their routine standard of care with TMZ therapy for approximately 6 months. Patients will be evaluated for response every 8 weeks. Patients will be followed up 2 years after the last dose of DSF-Cu.

Enrollment

23 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Histologically confirmed GBM (WHO grade IV).
The subject must have completed RT with concurrent TMZ at least 12 weeks prior to the planned start of treatment on this study UNLESS there is pathological verification of recurrent tumor and at least 4 weeks have elapsed since the end of RT with concurrent TMZ.
Experienced first unequivocal progression of tumor by magnetic resonance imaging (MRI) [as assessed via Radiologic Assessment in Neuro-Oncology (RANO) criteria within 3 months from the last dose of TMZ.
Karnofsky performance status (KPS) of at least 60%.
Willing to remain abstinent from consuming alcohol.
Recovered from the toxic effects of prior therapy to < grade 2 toxicity per NCI CTCAE prior to study registration (except lymphopenia).
Meets laboratory criteria for the following parameters: ANC, platelets, hemoglobin, total bilirubin, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, BUN and creatinine.
1. Females of childbearing potential must be willing to use an acceptable method of birth control (i.e., intra-uterine device, diaphragm with spermicide, condom with spermicide, or abstinence) for the duration of the study.

Exclusion criteria

Radiographic evidence of leptomeningeal dissemination, gliomatosis cerebri, infratentorial tumor, or disease at sites remote from the supratentorial brain.
Enrolled in another clinical trial testing a novel therapy or drug within the past 4 weeks.
Received more than one course of radiation therapy or more than a total dose of 75 Gy.
History of allergic reaction/hypersensitivity to temozolomide, dacarbazine, DSF or Cu.
Treatment with the following medications are contraindicated with DSF: metronidazole, isoniazid, dronabinol, carbocisteine, lopinavir, paraldehyde, ritonavir, sertraline, tindazole, tizanidine, atazanavir.
Fever within 3 days prior to study enrollment.
Active or severe hepatic or renal disease.
Grade 2 or higher peripheral neuropathy or ataxia per NCI CTCAE
History of idiopathic seizure disorder schizophrenia, or psychosis unrelated to glioblastoma, corticosteroid, or anti-epileptic medications.
History of Wilson's disease.
History of hemochromatosis.
Pregnant or breastfeeding.