Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Explorative Formulation of Insulin Degludec

Novo Nordisk

Status and phase

Completed

Phase 1

Conditions

Diabetes Mellitus, Type 1

Diabetes

Diabetes Mellitus, Type 2

Treatments

Drug: isophane human insulin

Drug: insulin degludec

Drug: placebo

Study type

Interventional

Funder types

Industry

Identifiers

NCT01865279

NN5401-1718

2005-003974-65 (EudraCT Number)

Details and patient eligibility

About

This trial is conducted in Europe. The aim of this trial is to investigate the safety, tolerability, pharmacokinetics (the exposure of the trial drug in the body) and pharmacodynamics (the effect of the investigated drug on the body) of insulin degludec (insulin 454), an explorative formulation, not similar to the proposed commerical formulation.

Enrollment

64 patients

Sex

Male

Ages

18 to 55 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

HEALTHY SUBJECTS:
Subjects will be healthy male subjects, who are considered to be generally healthy based on an assessment of medical history, physical examination and clinical laboratory data, as judged by the Investigator
Body mass index (BMI) between 18.0-27.0 kg/m^2 (both inclusive)
SUBJECTS WITH TYPE 1 AND TYPE 2 DIABETES:
Subjects will be male volunteers, who are considered to be generally healthy, except for the underlying diabetes mellitus, based on an assessment of medical history, physical examination and clinical laboratory data, as judged by the Investigator
Diagnosed with type 1 diabetes mellitus and treated with insulin for at least 12 months or diagnosed with type 2 diabetes mellitus for at least 12 months
Body Mass Index (BMI) between 18.0-27.0 kg/m^2 (both inclusive) for subjects with type 1 diabetes or 25.0-35.0 kg/m^2 (both inclusive) for subjects with type 2 diabetes
Glycogylated haemoglobin (HbA1c) maximum 8.5 % based on central laboratory results
Subjects with type 2 diabetes must have been treated with insulin for the past 3 months prior to screening

Exclusion criteria

Participation in any other trials involving investigational products within 3 months preceding the start of dosing
History of significant multiple drug allergies or with a known allergy to the trial product or any medicine chemically related to the trial product, as judged by the investigator
Hepatitis or carrier of the Hepatitis B surface antigen (HBsAg) or Hepatitis C antibodies or a positive result to the test for human immunodeficiency (HIV) antibodies
Any clinically significant abnormal haematology or biochemistry screening tests, as judged by the investigator
Subjects who have donated any blood or plasma in the past month or in excess of 1000 ml within the 12 weeks preceding screening