Salbutamol Use in Ozone Air Pollution by People With Asthma and/or Exercise Induced Bronchoconstriction (EIB)

University of British Columbia

Status and phase: Completed; Phase 4

Conditions: Asthma and/or Exercise Induced Bronchoconstriction; Ozone Air Pollution

Treatments: Drug: Placebo medication; Other: Exercise; Drug: Salbutamol; Other: Filtered Air; Other: Ozone

Study type: Interventional

Funder types: Other

Identifiers

NCT05087693

H21-01080

Details and patient eligibility

About

Salbutamol use is increased in areas with high levels of ozone pollution and the potential consequences of this are not well known. The purpose of this study is to examine the effect of salbutamol on lung function and inflammation in people with asthma and/or EIB exercising in ozone air pollution. To examine this, we are planning a randomized cross over trial where people with asthma and/or EIB complete sub maximal exercise in four conditions on four separate days. The four condition are: ozone + salbutamol, filtered air + salbutamol, ozone + placebo medication, and filtered air + placebo medication.

Enrollment: 18 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Have asthma and/or EIB
• Able to perform maximal exercise
• Able to communicate sufficiently using the English language

Exclusion criteria

• Allergic to salbutamol (also known as Ventolin)
• Pregnant or potentially pregnant
• Have a history of smoking
• Had an upper respiratory tract infection within the last 4 weeks
• Have a chronic respiratory disease other than asthma or EIB

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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18 participants in 4 patient groups, including a placebo group

Exercising in ozone following salbutamol inhalation

Experimental group

Description:

Participants will be doing sub-maximal exercise (60% of VO2max for 30 minutes) on a cycle ergometer while inhaling 170ppb ozone after inhaling 200ug of salbutamol.

Treatment:

Other: Ozone

Drug: Salbutamol

Other: Exercise

Exercising in filtered air following salbutamol inhalation

Active Comparator group

Description:

Participants will be doing sub-maximal exercise (60% of VO2max for 30 minutes) on a cycle ergometer while inhaling filtered air after inhaling 200ug of salbutamol.

Treatment:

Other: Filtered Air

Drug: Salbutamol

Other: Exercise

Exercising in ozone following placebo inhalation

Placebo Comparator group

Description:

Participants will be doing sub-maximal exercise (60% of VO2max for 30 minutes) on a cycle ergometer while inhaling 170ppb ozone after inhaling placebo medication.

Treatment:

Other: Ozone

Other: Exercise

Drug: Placebo medication

Exercising in filtered air following placebo inhalation

Placebo Comparator group

Description:

Participants will be doing sub-maximal exercise (60% of VO2max for 30 minutes) on a cycle ergometer while inhaling filtered after inhaling placebo medication.

Treatment:

Other: Filtered Air

Other: Exercise

Drug: Placebo medication